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Persistent vomiting, inability to keep fluids down, severe or radiating abdominal pain, or a stop in bowel movements are reasons to contact a clinician promptly, not to wait it out

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The authors acknowledged certain study limitations and emphasized that these findings underscore the need for patient-centered nutritional guidance, potentially involving Registered Dietitian Nutritionists, to optimize health outcomes and address identified dietary education gaps

The 2026 Cell Reports Medicine analysis found that GLP-1 receptor agonist treatment did upregulate certain mitochondrial proteins including SIRT5 in skeletal muscle compared to calorie restriction alone